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DFBP database
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List of peptide properties
DFBP ID - DFBPANHY0547(Antihypertensive peptide)
DFBP ID DFBPANHY0547
Peptide sequence PYVRYL
Type Native peptide
Peptide/Function name Antihypertensive peptide
Function-activity relationship
Main bioactivity Antihypertensive activity
Otheir bioactivity ACE-inhibitory activity [D1], Antioxidative activity [D2], Antimicrobial activity [D3], Multifunctional activity [D4]
Calculated physicochemical properties
Three-letter amino acid Pro-Tyr-Val-Arg-Tyr-Leu
Single-letter amino acid PYVRYL
Peptide length 6
Peptide mass
Experimental mass Theoretical mass
N.D 809.95 Da c
Net charge 0.00 c
Isoelectric point (pI) 9.59 c
IC50 N.D
pIC50 N.D
GRAVY -0.1167 c
Hydrophilic residue ratio 50% c
Peptide calculator
To calculate the physicochemical properties of bioactive peptide.
Peptide source & Food-borne protein(s) search
Classification Animal
Organism/Source Caprine milk protein, Caprine kefir
Precursor protein αs2-Casein
Residue position f(203-208)
Precursor protein(s) search
Link-research
 There are no literature reports on the discovery of this sequence in other food-source proteins.
Biological/Functional activity & target protein
Antihypertensive activity
Peptide
In vitro experiments
Dose (mg/kg)
SBP decrease
PYVRYLSHR
3.0
-23.4 mm Hg
Specific target protein(s) N.D
Taste properties & Structure
Bitterness
Literature report N.D
Bitter prediction tools Bitter taste prediction
SMILES N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Preparation method
Mode of preparation

Fermentation
Enzyme(s)/starter culture

Kefir was prepared using pasteurized milk cultured with kefir grains that contained the lactic acid bacteria Lactococcus lactis, Lactococcus cremoris, Lactococcus biovar. diacetylactis, Leuconostoc mesenteroides ssp. cremoris, Lactobacillus plantarum, Lactobacillus casei, and the yeast Kluyveromyces marxianus var. fragilis (Torula kefir).
Stability & Cytotoxicity
Peptide stability
Literature report: N.D
EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool)
Peptide cytotoxicity
Literature report: Non-Toxin
Prediction: ToxinPred
Additional information
Additional information N.D
Database cross-references
DFBP
[D1] DFBPACEI0278, DFBPACEI1727
[D2] DFBPANOX0715
[D3] DFBPAMIC0185
[D4] DFBPMUFU0387
BIOPEP-UWM [D5] 8152, 8178, 8262
APD [D6] -
BioPepDB [D7] -
MBPDB [D8] -
Reference(s)
Primary literature Quirós, A., Hernández-Ledesma, B., Ramos, M., Amigo, L., Recio, I. Angiotensin-Converting Enzyme Inhibitory Activity of Peptides Derived from Caprine Kefir. Journal of Dairy Science. 2005, 88, 3480-7.
Other literature(s)

[1] Martinez-Maqueda, D., et al., Antihypertensive peptides from food proteins: a review. Food Funct, 2012. 3(4): p. 350-361.
PubDate 2005
Copyright © 2020. Record / license number: Chongqing ICP No. 2000214